The SDN/NFV Cloud Computing Platform and Transport Network of the ADRENALINE Testbed

This work extends NFV paradigm to transport networks, known as Transport NFV. This paper presents a detailed overview of the SDN/NFV services that are offered on top of the Cloud Computing platform and transport network of the ADRENALINE Testbed. On the one hand, we propose a generic architecture for SDN/NFV services deployed over multi-domain transport networks and distributed data centers. On the other hand, we present two use cases of possible NFV services: a virtual Path Computation Element (vPCE) and the deployment of virtual SDN controllers (vSDN) on top of virtualized transport networks

Integrated IT and SDN Orchestration of multi-domain multi-layer transport networks

Telecom operators networks' management and control remains partitioned by technology, equipment supplier and networking layer. In some segments, the network operations are highly costly due to the need of the individual, and even manual, configuration of the network equipment by highly specialized personnel. In multi-vendor networks, expensive and never ending integration processes between Network Management Systems (NMSs) and the rest of systems (OSSs, BSSs) is a common situation, due to lack of adoption of standard interfaces in the management systems of the different equipment suppliers. Moreover, the increasing impact of the new traffic flows introduced by the deployment of massive Data Centers (DCs) is also imposing new challenges that traditional networking is not ready to overcome. The Fifth Generation of Mobile Technology (5G) is also introducing stringent network requirements such as the need of connecting to the network billions of new devices in IoT paradigm, new ultra-low latency applications (i.e., remote surgery) and vehicular communications. All these new services, together with enhanced broadband network access, are supposed to be delivered over the same network infrastructure. In this PhD Thesis, an holistic view of Network and Cloud Computing resources, based on the recent innovations introduced by Software Defined Networking (SDN), is proposed as the solution for designing an end-to-end multi-layer, multi-technology and multi-domain cloud and transport network management architecture, capable to offer end-to-end services from the DC networks to customers access networks and the virtualization of network resources, allowing new ways of slicing the network resources for the forthcoming 5G deployments. The first contribution of this PhD Thesis deals with the design and validation of SDN based network orchestration architectures capable to improve the current solutions for the management and control of multi-layer, multi-domain backbone transport networks. These problems have been assessed and progressively solved by different control and management architectures which has been designed and evaluated in real evaluation environments. One of the major findings of this work has been the need of developed a common information model for transport network's management, capable to describe the resources and services of multilayer networks. In this line, the Control Orchestration Protocol (COP) has been proposed as a first contriution towards an standard management interface based on the main principles driven by SDN. Furthermore, this PhD Thesis introduces a novel architecture capable to coordinate the management of IT computing resources together with inter- and intra-DC networks. The provisioning and migration of virtual machines together with the dynamic reconfiguration of the network has been successfully demonstrated in a feasible timescale. Moreover, a resource optimization engine is introduced in the architecture to introduce optimization algorithms capable to solve allocation problems such the optimal deployment of Virtual Machine Graphs over different DCs locations minimizing the inter-DC network resources allocation. A baseline blocking probability results over different network loads are also presented. The third major contribution is the result of the previous two. With a converged cloud and network infrastructure controlled and operated jointly, the holistic view of the network allows the on-demand provisioning of network slices consisting of dedicated network and cloud resources over a distributed DC infrastructure interconnected by an optical transport network. The last chapters of this thesis discuss the management and orchestration of 5G slices based over the control and management components designed in the previous chapters. The design of one of the first network slicing architectures and the deployment of a 5G network slice in a real Testbed, is one of the major contributions of this PhD Thesis.La gestión y el control de las redes de los operadores de red (Telcos), todavía hoy, está segmentado por tecnología, por proveedor de equipamiento y por capa de red. En algunos segmentos (por ejemplo en IP) la operación de la red es tremendamente costosa, ya que en muchos casos aún se requiere con guración individual, e incluso manual, de los equipos por parte de personal altamente especializado. En redes con múltiples proveedores, los procesos de integración entre los sistemas de gestión de red (NMS) y el resto de sistemas (p. ej., OSS/BSS) son habitualmente largos y extremadamente costosos debido a la falta de adopción de interfaces estándar por parte de los diferentes proveedores de red. Además, el impacto creciente en las redes de transporte de los nuevos flujos de tráfico introducidos por el despliegue masivo de Data Centers (DC), introduce nuevos desafíos que las arquitecturas de gestión y control de las redes tradicionales no están preparadas para afrontar. La quinta generación de tecnología móvil (5G) introduce nuevos requisitos de red, como la necesidad de conectar a la red billones de dispositivos nuevos (Internet de las cosas - IoT), aplicaciones de ultra baja latencia (p. ej., cirugía a distancia) y las comunicaciones vehiculares. Todos estos servicios, junto con un acceso mejorado a la red de banda ancha, deberán ser proporcionados a través de la misma infraestructura de red. Esta tesis doctoral propone una visión holística de los recursos de red y cloud, basada en los principios introducidos por Software Defined Networking (SDN), como la solución para el diseño de una arquitectura de gestión extremo a extremo (E2E) para escenarios de red multi-capa y multi-dominio, capaz de ofrecer servicios de E2E, desde las redes intra-DC hasta las redes de acceso, y ofrecer ademas virtualización de los recursos de la red, permitiendo nuevas formas de segmentación en las redes de transporte y la infrastructura de cloud, para los próximos despliegues de 5G. La primera contribución de esta tesis consiste en la validación de arquitecturas de orquestración de red, basadas en SDN, para la gestión y control de redes de transporte troncales multi-dominio y multi-capa. Estos problemas (gestion de redes multi-capa y multi-dominio), han sido evaluados de manera incremental, mediante el diseño y la evaluación experimental, en entornos de pruebas reales, de diferentes arquitecturas de control y gestión. Uno de los principales hallazgos de este trabajo ha sido la necesidad de un modelo de información común para las interfaces de gestión entre entidades de control SDN. En esta línea, el Protocolo de Control Orchestration (COP) ha sido propuesto como interfaz de gestión de red estándar para redes SDN de transporte multi-capa. Además, en esta tesis presentamos una arquitectura capaz de coordinar la gestión de los recursos IT y red. La provisión y la migración de máquinas virtuales junto con la reconfiguración dinámica de la red, han sido demostradas con éxito en una escala de tiempo factible. Además, la arquitectura incorpora una plataforma para la ejecución de algoritmos de optimización de recursos capaces de resolver diferentes problemas de asignación, como el despliegue óptimo de Grafos de Máquinas Virtuales (VMG) en diferentes DCs que minimizan la asignación de recursos de red. Esta tesis propone una solución para este problema, que ha sido evaluada en terminos de probabilidad de bloqueo para diferentes cargas de red. La tercera contribución es el resultado de las dos anteriores. La arquitectura integrada de red y cloud presentada permite la creación bajo demanda de "network slices", que consisten en sub-conjuntos de recursos de red y cloud dedicados para diferentes clientes sobre una infraestructura común. El diseño de una de las primeras arquitecturas de "network slicing" y el despliegue de un "slice" de red 5G totalmente operativo en un Testbed real, es una de las principales contribuciones de esta tesis.La gestió i el control de les xarxes dels operadors de telecomunicacions (Telcos), encara avui, està segmentat per tecnologia, per proveïdors d’equipament i per capes de xarxa. En alguns segments (Per exemple en IP) l’operació de la xarxa és tremendament costosa, ja que en molts casos encara es requereix de configuració individual, i fins i tot manual, dels equips per part de personal altament especialitzat. En xarxes amb múltiples proveïdors, els processos d’integració entre els Sistemes de gestió de xarxa (NMS) i la resta de sistemes (per exemple, Sistemes de suport d’operacions - OSS i Sistemes de suport de negocis - BSS) són habitualment interminables i extremadament costosos a causa de la falta d’adopció d’interfícies estàndard per part dels diferents proveïdors de xarxa. A més, l’impacte creixent en les xarxes de transport dels nous fluxos de trànsit introduïts pel desplegament massius de Data Centers (DC), introdueix nous desafiaments que les arquitectures de gestió i control de les xarxes tradicionals que no estan llestes per afrontar. Per acabar de descriure el context, la cinquena generació de tecnologia mòbil (5G) també presenta nous requisits de xarxa altament exigents, com la necessitat de connectar a la xarxa milers de milions de dispositius nous, dins el context de l’Internet de les coses (IOT), o les noves aplicacions d’ultra baixa latència (com ara la cirurgia a distància) i les comunicacions vehiculars. Se suposa que tots aquests nous serveis, juntament amb l’accés millorat a la xarxa de banda ampla, es lliuraran a través de la mateixa infraestructura de xarxa. Aquesta tesi doctoral proposa una visió holística dels recursos de xarxa i cloud, basada en els principis introduïts per Software Defined Networking (SDN), com la solució per al disseny de una arquitectura de gestió extrem a extrem per a escenaris de xarxa multi-capa, multi-domini i consistents en múltiples tecnologies de transport. Aquesta arquitectura de gestió i control de xarxes transport i recursos IT, ha de ser capaç d’oferir serveis d’extrem a extrem, des de les xarxes intra-DC fins a les xarxes d’accés dels clients i oferir a més virtualització dels recursos de la xarxa, obrint la porta a noves formes de segmentació a les xarxes de transport i la infrastructura de cloud, pels propers desplegaments de 5G. La primera contribució d’aquesta tesi doctoral consisteix en la validació de diferents arquitectures d’orquestració de xarxa basades en SDN capaces de millorar les solucions existents per a la gestió i control de xarxes de transport troncals multi-domini i multicapa. Aquests problemes (gestió de xarxes multicapa i multi-domini), han estat avaluats de manera incremental, mitjançant el disseny i l’avaluació experimental, en entorns de proves reals, de diferents arquitectures de control i gestió. Un dels principals troballes d’aquest treball ha estat la necessitat de dissenyar un model d’informació comú per a les interfícies de gestió de xarxes, capaç de descriure els recursos i serveis de la xarxes transport multicapa. En aquesta línia, el Protocol de Control Orchestration (COP, en les seves sigles en anglès) ha estat proposat en aquesta Tesi, com una primera contribució cap a una interfície de gestió de xarxa estàndard basada en els principis bàsics de SDN. A més, en aquesta tesi presentem una arquitectura innovadora capaç de coordinar la gestió de els recursos IT juntament amb les xarxes inter i intra-DC. L’aprovisionament i la migració de màquines virtuals juntament amb la reconfiguració dinàmica de la xarxa, ha estat demostrat amb èxit en una escala de temps factible. A més, l’arquitectura incorpora una plataforma per a l’execució d’algorismes d’optimització de recursos, capaços de resoldre diferents problemes d’assignació, com el desplegament òptim de Grafs de Màquines Virtuals (VMG) en diferents ubicacions de DC que minimitzen la assignació de recursos de xarxa entre DC. També es presenta una solució bàsica per a aquest problema, així com els resultats de probabilitat de bloqueig per a diferents càrregues de xarxa. La tercera contribució principal és el resultat dels dos anteriors. Amb una infraestructura de xarxa i cloud convergent, controlada i operada de manera conjunta, la visió holística de la xarxa permet l’aprovisionament sota demanda de "network slices" que consisteixen en subconjunts de recursos d’xarxa i cloud, dedicats per a diferents clients, sobre una infraestructura de Data Centers distribuïda i interconnectada per una xarxa de transport òptica. Els últims capítols d’aquesta tesi tracten sobre la gestió i organització de "network slices" per a xarxes 5G en funció dels components de control i administració dissenyats i desenvolupats en els capítols anteriors. El disseny d’una de les primeres arquitectures de "network slicing" i el desplegament d’un "slice" de xarxa 5G totalment operatiu en un Testbed real, és una de les principals contribucions d’aquesta tesi.Postprint (published version

Improving Security in Internet of Things with Software Defined Networking

Future Internet of Things (IoT) will connect to the Internet billions of heterogeneous smart devices with the capacity of interacting with the environment. Therefore, the proposed solutions from an IoT networking perspective must take into account the scalability of IoT nodes as well as the operational cost of deploying the networking infrastructure. This will generate a huge volume of data, which poses a tremendous challenge both from the transport, and processing of information point of view. Moreover, security issues appear, due to the fact that untrusted IoT devices are interconnected towards the aggregation networks. In this paper, we propose the usage of a Software- Defined Networking (SDN) framework for introducing security in IoT gateways. An experimental validation of the framework is proposed, resulting in the enforcement of network security at the network edge

Traffic Engineering enforcement in multi-domain SDN orchestration of Multi-Layer (packet/optical) networks

We introduce an SDN orchestration architecture to enable the introduction of E2E TE policies in a multi-domain, multi-layer network scenario. The ABNO is used as reference architecture for the SDN orchestration of packet/optical SDN controllers using Flow Service Classification. Grant numbers : EC's to the Spanish MINECO project FARO (TEC2012-38119).© 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. Document type: Conference objec

The Iron Age Iberian sanctuary of 'El Pajarillo' (Huelma, Jaén) and its sculptural narrative

This article is a result of the research project BHA200s-02881: 'Landscape, economic activities and social models during lberian times along the upper course of the Guadalquivir river' (Spanish Ministry of Education).Peer Reviewe

Allograft Survival without Immunosuppression in Landrace Pigs after 90 Days

ABSTRACT Allotransplantation is helpful in order to maintain the life in some cases, but immunosuppression causes collateral effects. In this study, we were reporting the results of allografts in Landrace pigs, which were implanted on collagen-generator devices. After 2 weeks of implantation, the devices were carried out to assess allograft viability at 30, 60 and 90 days post implant. The implanted cells were islets of Langerhans and the aim was to prove their presence by immunohistochemistry for insulin and glucagon. The results were positive at 30, 60 and 90 days post implant. It demonstrated that the collagen-generator device permits the cell viability without using anti-rejected drugs or immunomodulating cells

Exceptional oxidation activity with size-controlled supported gold clusters of low atomicity

[EN] The catalytic activity of gold depends on particle size, with the reactivity increasing as the particle diameter decreases. However, investigations into behaviour in the subnanometre regime (where gold exists as small clusters of a few atoms) began only recently with advances in synthesis and characterization techniques. Here we report an easy method to prepare isolated gold atoms supported on functionalized carbon nanotubes and their performance in the oxidation of thiophenol with O-2. We show that single gold atoms are not active, but they aggregate under reaction conditions into gold clusters of low atomicity that exhibit a catalytic activity comparable to that of sulfhydryl oxidase enzymes. When clusters grow into larger nanoparticles, catalyst activity drops to zero. Theoretical calculations show that gold clusters are able to activate thiophenol and O-2 simultaneously, and larger nanoparticles are passivated by strongly adsorbed thiolates. The combination of both reactants activation and facile product desorption makes gold clusters excellent catalysts.Financial support from the Spanish Science and Innovation Ministry (Consolider Ingenio 2010-MULTICAT CSD2009-00050, Subprograma de apoyo a Centros y Universidades de Excelencia Severo Ochoa SEV 2012 0267, MAT2011-28009 and MAT2010-20442 projects) and Xunta de Galicia (Grupos Ref.Comp.2010/41) is acknowledged. M.J.Y. and E. L. acknowledge the support of the National Centre for Research Resources (5 G12RR013646-12) and the National Institute on Minority Health and Health Disparities (G12MD007591) from the National Institutes of Health and of the National Science Foundation for support with grants DMR-1103730 and PREM: NSF PREM Grant # DMR 0934218. We also acknowledge the support of Consejo Nacional De Ciencia y Tecnologia. 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Selective oxidation with dioxygen by gold nanoparticle catalysts derived from 55-atom clusters. Nature 454, 981–983 (2008).Liu, Y. M., Tsunoyama, H., Akita, T. & Tsukuda, T. Chem. Commun. 46, 550–552 (2010).Shichibu, Y. & Konishi, K. HCl-induced nuclearity convergence in diphosphine-protected ultrasmall gold clusters: a novel synthetic route to ‘magic-number’ Au13 clusters. Small 6, 1216–1220 (2010).Xie, S., Tsunoyama, H., Kurashige, W., Negishi, Y. & Tsukuda, T. Enhancement in aerobic alcohol oxidation catalysis of Au25 clusters by single Pd atom doping. ACS Catal. 2, 1519–1523 (2012).Sanchez, A. et al. When gold is not noble: nanoscale gold catalysts. J. Phys. Chem. A 103, 9573–9578 (1999).Hoober, K. L. & Thorpe, C. Egg white sulfhydryl oxidase: kinetic mechanism of the catalysis of disulfide bond formation. Biochemistry 38, 3211–3217 (1999).Jaje, J. et al. A flavin-dependent sulfhydryl oxidase in bovine milk. Biochemistry 46, 13031–13040 (2007).Dumont, E., Michel, C. & Sautet, P. 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Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation